The following is a list of geocaches that can be found at rest areas along Interstate 81. In keeping with interstate mile numbering systems, they are listed from south to north.
- I-81 joins I-64 in Lexington.
- I-81 separates from I-64 in Staunton.
- Blue Star I-81 northbound, at the West Virginia Welcome center.
- I-81 meets I-70 in Hagerstown.